Biomaterials: Selection and Testing
Goal:
To choose a viable biomaterial for use in electrospinning that satisfies the requirement for biocompatilibity and electrospinning.
The selection of biomaterials for the inner core and the outer shell are essential to creating a hybrid tissue scaffold capable of acting as a drug delivery system of NGF to differentiate PC-12 cells. The main specifications of all the materials include being biodegradable, biocompatible with tissues in the human body as well as with the other biomaterials being selected, not releasing toxic fumes and other toxic byproducts, and closely mimicking the native body/ECM. Type I collagen in combination with PEO were selected for the outer shell. Alginic acid sodium salt from brown algae and calcium chloride were selected for the hydrogel and crosslinking agent, respectively, for the inner core. In conclusion, the materials were selected to meet the proper specifications and constraints of the project.
To choose a viable biomaterial for use in electrospinning that satisfies the requirement for biocompatilibity and electrospinning.
The selection of biomaterials for the inner core and the outer shell are essential to creating a hybrid tissue scaffold capable of acting as a drug delivery system of NGF to differentiate PC-12 cells. The main specifications of all the materials include being biodegradable, biocompatible with tissues in the human body as well as with the other biomaterials being selected, not releasing toxic fumes and other toxic byproducts, and closely mimicking the native body/ECM. Type I collagen in combination with PEO were selected for the outer shell. Alginic acid sodium salt from brown algae and calcium chloride were selected for the hydrogel and crosslinking agent, respectively, for the inner core. In conclusion, the materials were selected to meet the proper specifications and constraints of the project.